Xeomin vs. Dysport: How They Differ

What Is Xeomin?

Xeomin is an FDA-approved neurotoxin injectable designed to improve the appearance of moderate to severe frown lines in the glabellar (eyebrow) area. Xeomin does this by temporarily freezing facial muscles that cause the appearance of lines and furrows.

Xeomin is the so-called “naked” neurotoxin, containing only the purified form of its active ingredient – Botulinum toxin type A – without additional complexing proteins. Because of this, there is a lower risk of triggering an immune response and developing resistance to the treatment over time.

Note: Read about Botox resistance and effective ways to prevent it.

What Is Dysport?

Dysport is an FDA-approved neurotoxin injectable that blocks nerve signals to the muscles in the glabellar area, temporarily relaxing the muscles and smoothing the skin for a more youthful, rejuvenated appearance.

Dysport is the brand name of the neuromuscular blocker “AbobotulinumtoxinA” and is primarily used for treating moderate to severe frown (glabellar) lines. Its unique formulation contains complexing proteins and spreads faster than other neurotoxins, such as Botox and Xeomin, making it ideal for larger areas (e.g., forehead).

Note: Learn about the difference between Botox and Dysport.

What Are the Differences Between Xeomin and Dysport?

Xeomin and Dysport both use botulinum toxin as their main ingredient, but differ in how quickly they spread, whether they contain added ingredients, and their expected results. They are often used interchangeably, depending on the patient’s prior experience and desired effect.

Xeomin vs. Dysport Ingredients and Formula

The key difference between Xeomin and Dysport lies in their formulation and added ingredients.

Xeomin

Xeomin contains only Botulinum toxin type Aas its active ingredient and is free of additives or complexing proteins, thereby minimizing the risk of allergic reactions.

Its purified formula has a more localized diffusion pattern than Dysport, allowing better precision at the injection site and a reduced risk of unintentional spread to nearby muscles. This makes it suitable for smaller or more delicate areas that require tighter control, such as Crow’s feet.

Dysport

Dysport contains the active Botulinum toxin type A, as well as complexing proteins and additives, making its formula more similar to Botox. The accessory proteins prolong the effects of the treatment and help the toxin reach its destination, but may cause allergic reactions in some patients.

What Areas Can Be Treated with Xeomin and Dysport?

The FDA approved both Xeomin and Dysport for the treatment of forehead lines. However, providers also use them off-label to treat other areas.

Xeomin is typically used for the precise treatment of smaller or delicate areas, while Dysport is favored for broader or stronger muscle areas because it tends to diffuse more widely.

Xeomin vs. Dysport Dosage

The number of units depends on facial structure, muscle strength, the severity of the wrinkles, treatment area, and the patient’s medical history.

The table below shows the recommended dosages used for treating different areas.

Note: One Xeomin unit is equivalent to approximately 3 Dysport units due to its formulation and dispersion rate.

How to Prepare for Xeomin and Dysport?

To ensure optimal results and minimize the risk of swelling or bruising, follow these guidelines:

• Schedule a consultation to discuss treatment goals and inform the provider of existing allergies, recent vaccinations, and prior reactions to injectables.
• Tell your injector if you are pregnant, breastfeeding, or have a neuromuscular condition.
• Avoid blood-thinning medications and supplements, including aspirin, ibuprofen, fish oil, vitamin E, and ginkgo biloba for at least 48 hours before treatment.
• Avoid alcoholic beverages and high-intensity workouts 24 hours before the appointment.
• Arrive with a clean, makeup-free face and use gentle, biome-friendly skincare products.
• Avoid harsh ingredients, exfoliating acids, retinol-based products, and treatments like waxing, laser resurfacing, or chemical peels.
• Hydrate well and consume a light, nutritious meal to prevent lightheadedness.

What to Expect During a Xeomin and Dysport Procedure?

Xeomin and Dysport are quick, minimally painful procedures. Most patients report feeling a series of light pinches or pricking sensations.

The procedure lasts 10 to 20 minutes and includes the following steps:

1. Consultation – Before the treatment, patients meet with their medical provider to discuss their goals, medical history, potential side effects, and downtime. The medical provider assesses the patient’s facial structure and skin condition to recommend the most appropriate treatment and the number of units needed for optimal results.
2. Preparation – The medical provider gently cleanses the face, applies a topical treatment such as lidocaine to minimize discomfort, and marks the injection spots.
3. Insertion – The medical provider injects Xeomin or Dysport with a fine needle. The treatment lasts a couple of minutes, and the number of units required varies by patient and facial region.
4. Aftercare – Downtime is minimal, and the medical provider may recommend applying ice packs to the treated area and avoiding heavy exercise, sun exposure, or lying down too soon after the treatment.
5. Follow-up – The medical provider schedules a follow-up consultation 2 weeks after the procedure to review results and potential side effects.

Note: Read a more in-depth article about Xeomin aftercare protocol.

What Are the Results of Xeomin and Dysport?

Both injectables deliver fast results that typically last 3 to 4 months. Some patients report differences in longevity and onset of action, but these vary depending on the patient’s metabolism, the number of units, and the treatment area.

Xeomin

The results of Xeomin may take up to 4 days to appear because its single active ingredient takes longer to take effect. They typically last from 3 to 6 months, depending on the body’s ability to adjust to the treatment.

Providers recommend regular touchups to prolong the smoothing effects of the treatment.

Dysport

The results of Dysport may be visible within 24 hours because the complexing proteins bind together, speeding up their onset and making them more effective. They typically last up to 4 months, depending on the frequency of touchups and the patient’s muscle structure.

Note: Learn how long it takes for Dysport to work and how long Xeomin lasts.

What Are the Side Effects of Xeomin and Dysport?

Both Xeomin and Dysport can cause temporary side effects that range from mild to moderate. Following an aftercare protocol recommended by your provider will ensure faster recovery.

Mild side effects include:

• Bruising
• Swelling
• Bleeding at the injection site
• Pain
• Redness
• Skin sensitivity
• Flu-like symptoms

Severe symptoms are far less common, and they include:

• Allergic reactions
• Blurred vision
• Dizziness
• Nervousness
• Headaches
• Ear pounding
• Irregular heartbeat
• Chest tightness

If you experience any of these side effects, do not hesitate to contact your medical provider as soon as possible to receive proper treatment.

Note: Discover the most effective ways to prevent and alleviate the side effects of Xeomin.

Xeomin vs. Dysport Cost

Xeomin’s per-unit price is higher than Dysport’s. However, while you may spend more upfront on Xeomin, it can also be more cost-effective because it requires fewer units than Dysport.

At Vibrant Skin Bar, you can purchase Xeomin for $14 and Dysport for $4.67 per unit.

Which Is Better, Xeomin or Dysport?

The choice between Xeomin and Dysport is based on your personal preferences and your provider’s recommendation, as both are equally effective at erasing signs of premature aging.

Xeomin may be preferable for the following reasons:

• Less likely to cause an allergic reaction due to its purified formula.
• Tighter diffusion improves precision and provides a more “targeted” treatment.
• Ideal for smaller, delicate, or highly expressive regions.
• Fewer units are required compared to Dysport.

Dysport is often recommended to individuals seeking:

• Treatments in larger areas with stronger muscles.
• Smoother blending across large surfaces.
• Slightly faster onset of action (no clinical data, only anecdotal evidence).

Additionally, people allergic to milk or eggs should avoid Dysport, but may safely have Xeomin and other neuromodulators.

Our experts at Vibrant Skin Bar can help you reach a decision and guide you through this process, creating a treatment tailored to your needs and physiology.

Note: Compare Dysport to Restylane to find out which suits you better.

Can You Get Dysport and Xeomin at the Same Time?

Dysport and Xeomin can be administered simultaneously, but not in the same area. Mixing these two neurotoxins has not been clinically tested, but using them at separate locations during a single session is possible. Choosing a reputable injector who knows how to adjust the dosages and expertly handle different injection angles is vital.

Some providers may customize the treatment, using both Dysport and Xeomin to leverage their unique strengths. For example, they may use Xeomin for deeper frown lines or more delicate areas around the eyes, while injecting Dysport into broader forehead areas.

While mixing is possible, the decision comes down to your aesthetic goals and the injection technique of your chosen provider.

Conclusion

Both Xeomin and Dysport offer safe and effective solutions for temporarily reducing facial wrinkles. Choosing between them should be based on individual needs, preferences, and the expertise of the administering medical provider. A thorough consultation with a qualified professional is essential to determine the most suitable option and create a personalized treatment plan for achieving natural-looking and satisfactory results.

For Xeomin and Dysport injections near the Phoenix area, reach out to our medical professionals at Vibrant Skin Bar to schedule a consultation.