Phentermine is a central nervous system (CNS) stimulant drug that works as an appetite suppressant and is available only on prescription. Medical weight loss experts may add it to a dieting and exercise regime to help their patients kickstart their weight loss journey.
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Read about how phentermine for weight loss works, how to take it, and what to expect, and find out if it is suitable for you.
Phentermine belongs to the class of drugs called anorectics or anorexigenics, also known as appetite suppressants. It increases the levels of the brain’s neurotransmitters, norepinephrine, dopamine, and serotonin. Higher amounts of these chemicals induce a feeling of fullness, thereby minimizing food cravings, reducing calorie intake, and gradually leading to weight loss.
The exact way phentermine works to suppress appetite remains unclear. Some patients develop a tolerance to it over time and may require a medication switch.
Some weight-reducing pills (e.g., Qsymia) contain phentermine and topiramate to speed up weight loss on calorie-restricted diets.
According to a study published in the Annals of Pharmacotherapy, you can lose 10% to 11% of total body mass after a year of taking Qsymia (15mg phentermine/92mg topiramate). Other studies (like this one and this one) found that the rate of weight loss is higher in the earlier months of therapy and that it decreases with prolonged use.
The speed of a patient’s weight speed will depend on the following factors:
Patients can expect additional weight-related improvements, such as reduced belly fat, lower blood pressure, blood sugar, and cholesterol.
Note: Discover the best appetite suppressants to manage cravings.
Phentermine is a short-term weight loss aid with multiple benefits, including the following:
Phentermine shows no significant side effects as a short-term weight loss medication. However, there is inconclusive evidence to confirm its long-term safety.
The FDA-approved combination of phentermine and topiramate in reduced dosages is a safer, long-term solution for losing weight. Nonetheless, some risks and side effects are involved.
Common side effects are mild and temporary, including the following:
Serious complications occur rarely and require immediate medical assistance. They include the following:
Do not change the dosage without consulting the doctor. If you stop using this medication abruptly, you may experience some of the following withdrawal symptoms:
Withdrawal is more likely if you have used phentermine in higher dosages or for an extended period. Patients with a history of substance abuse may develop addiction to phentermine, too.
Your doctor may lower the dosage or prescribe medication to alleviate the symptoms. Seek prompt medical help if you notice any of the mentioned symptoms.
Phentermine may interact with 174 prescription and over-the-counter drugs, including the following:
A dangerous drug interaction may occur with monoamine oxidase inhibitors (MAOIs):
Do not self-medicate with phentermine. Seek medical advice to learn more about its safety, optimal dosage, and potential drug interactions.
Note: If you are considering other weight loss options, check out our list of the best weight loss products.
Doctors prescribe phentermine to adults and children aged 12 years or older with an initial BMI equal to or in excess of 30 kg/m2, which falls within the obesity range.
Phentermine is typically prescribed to individuals who have not been able to lose excess weight with other diet pills, or who have additional weight-related medical conditions (e.g., high cholesterol, type 2 diabetes, high blood pressure).
Use of phentermine is contraindicated if the patient has any of the following conditions:
A pregnancy test should be done before starting this medication and as needed while using this medication. Blood pressure and heart rate should be checked and monitored. Patients should also be monitored for suicide ideation and mood changes.
The recommended FDA-approved dosage is one 8-mg pill taken three times a day, at least 30 minutes before meals. Doctors may prescribe a higher dosage (e.g., 15, 30, or 37.5 mg) that you can take once a day, either before breakfast or 1-2 hours after breakfast.
The phentermine and topiramate blend (i.e., Qsymia) is an extended-release capsule taken in the morning. It is available in four doses (3.75-15 mg of phentermine and 23-92 of topiramate).
Take phentermine by mouth with a glass of water, as directed by your doctor. Do not crush or chew, and do not take more than directed. In case of overdosage, contact an emergency room immediately.
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Phentermine can help patients lose weight in combination with a reduced-calorie diet, exercise, and behavior changes. Doctors usually prescribe it to people who have had no significant improvements with other lifestyle modifications, dieting programs, and exercise plans.
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