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The 18 Best iS Clinical Products for a Healthy, Glowing Skin

Kristina Cadwell  
December 22, 2022  

The market is saturated with skincare products, making it challenging to find cleansers, serums, and creams that do what they claim. One thing that can help in the evaluation process is a recommendation from skin experts.

iS Clinical is a medical-grade cosmetic brand that has repeatedly received praise from dermatologists and cosmetics professionals. Our team at Vibrant Skin Bar has tested many of their products and confirms they deliver outstanding results.

The following is a list of 18 iS Clinical products to put on your radar, with explanations how the ingredients work to improve specific skin conditions.

18 iS Clinical Products to Try

1. Active Serum

iS Clinical Active Serum

Active Serum is the brand’s flagship product, favored by many celebrities. Users swear by it because the improvement in skin tone and texture can be seen after only a few applications.

The key ingredients include:

  • Arbutin - a molecule with a brightening effect; helps treat hyperpigmentation.
  • White willow bark extract - has anti-inflammatory, soothing properties and minimizes redness.
  • Sugar cane extract - a powerful humectant and exfoliant; helps to moisturize and gently renew the skin.
  • Bilberry extract - additionally moisturizes and exfoliates the skin.

This highly concentrated botanical blend effectively minimizes fine lines and wrinkles, dark spots, blemishes, and scars and provides long-lasting results.

Apply it in a thin layer on clean skin, including the neck.

At Vibrant Skin Bar, Active Serum (1 oz) bottle costs $142.

2. Brightening Complex

iS Clinical Brightening Complex

Brightening Complex is a rich blend of pharmaceutical-grade botanicals that act on all mechanisms contributing to a tired, uneven complexion. It gently exfoliates, hydrates, and protects the skin.

Its active ingredients, arbutin, licorice root, and vitamin C, provide a potent brightening effect, while superstar humectants, glycerin, squalene, hyaluronic acid, and Imperata Cylindrica root extract provide deep hydration.

The result is a smoother, clearer skin tone and a plumper, rejuvenated complexion.

Apply it thinly on a clean face and neck in the morning and evening.

At Vibrant Skin Bar, Brightening Complex (1 oz) costs $148.

Note: Find out what other products and treatments can help rejuvenate skin.

3. Brightening Serum

iS Clinical Brightening Serum

This concentrated lightening formula improves pigmentation issues, including melasma, discoloration, and blemishes.

Brightening Serum’s key brightening ingredients include arbutin and Norwegian kelp extract, while white willow bark, sugar cane, and bilberry extracts provide deep hydration, gentle exfoliation, and soothe the skin.

Apply a small amount on the face and neck or only on hyperpigmented areas.

At Vibrant Skin Bar, Brightening Serum (1 oz) costs $135.

4. Cleansing Complex

iS Clinical Cleansing Complex

Cleansing Complex is a lightweight, soothing product formulated to thoroughly cleanse the skin’s surface and pores without stripping the skin of natural oils.

The product’s active ingredients, chamomile flower extract and Centella asiatica, have potent antioxidant properties, protecting the skin from environmental factors and minimizing premature aging signs. They also nourish the skin and have a calming effect, which helps prevent potential irritation and redness from the resurfacing effects of sugar cane and white willow bark extracts.

Apply a thin layer on damp skin on the face and neck twice daily, massage gently, and rinse.

At Vibrant Skin Bar, Cleansing Complex (6 oz) costs $45.

5. Copper Firming Mist

iS Clinical Copper Firming Mist

Copper Firming Mist is a handy moisturizing spray you can carry in your purse and use whenever your skin needs refreshing (in airplanes, AC spaces, dry or hot areas, etc.).

It is infused with botanical antioxidants, such as resveratrol, which support the skin’s protective barrier and noticeably firm it. The added benefit of the product’s firming properties is that they help keep makeup in place all day.

Note: Wondering what resveratrol does for you? Check out our guide on why and how to use resveratrol for skin care.

Copper PCA regulates sebum and minimizes aging signs.

Spray the product on the face and neck whenever your skin feels tight and dehydrated.

At Vibrant Skin Bar, Copper Firming Mist (2.5 oz) costs $40.

Note: Learn what causes dry skin and how to treat it.

6. GeneXC Serum

iS Clinical GeneXC Serum

Another potent brightening serum by iS Clinical, GeneXC is clinically proven to provide multi-level protection and nourishment to the skin.

The product is infused with botanically sourced enzymes, vitamin C, and other antioxidants and fruit acids, supporting collagen and elastin production and helping to maintain the skin’s glow and suppleness.

The product’s star ingredients include:

  • Superoxide dismutase (SOD) - an antioxidant that supports healthy skin and minimizes the signs of photodamage.
  • L-ascorbic acid - a form of vitamin C that soothes the skin and lessens the signs of photodamage.
  • Kakadu plum extract - a potent antioxidant with brightening effects that helps diminish redness and provides a more even skin tone.
  • Green tea - an antioxidant with powerful UV-protective, anti-inflammatory, and anti-aging properties.

The serum helps diminish fine lines and wrinkles, blemishes, rosacea, acne, and other imperfections while keeping the skin hydrated and healthy.

Apply a few drops and pat evenly over dry, clean skin on the face and neck. Use it once or twice a day.

At Vibrant Skin Bar, GeneXC Serum (1 oz) costs $170.

7. HydraCool Serum

iS Clinical Hydracool Serum

HydraCool Serum is a refreshing serum infused with potent antioxidants and rich botanicals, providing intense hydration and anti-aging protection.

Vitamin B5 in the product supports a healthy complexion, mushroom extract brightens the skin, minimizing spots and blemishes, and hyaluronic acid deeply hydrates it. The serum’s soothing qualities make it an excellent remedy for sunburned skin.

Apply a thin layer on clean skin in the morning and evening.

At Vibrant Skin Bar, HydraCool Serum (1 oz) costs $96.

8. Lip Duo

iS Clinical Lip Duo

Lip duo is a package of two products for the lips, Lip Polish and Youth Lip Elixir.

Lip Polish is a gentle lip scrub infused with superior antioxidants and hydrating botanicals that help treat and prevent dry lips.

Youth Lip Elixir intensely hydrates the lips, giving them a softer and plumper appearance.

Lip Duo’s key ingredients include:

  • Sucrose - a natural exfoliator that gently removes impurities from the surface and balances the lips’ natural oils.
  • Vitamin C - protects the lips from UV radiation and environmental factors.
  • Vitamin E - provides additional protection against signs of photoaging.
  • Hyaluronic acid -  intensely hydrates, helping to smooth and plump the lips.
  • Shea and cocoa butter - provides more hydration and protection against environmental pollutants.

Apply Lip Polish in a thin layer on damp lips and massage them using circular motions. Rinse with lukewarm water and pat dry. Use the product two or three times a week. Use Lip Elixir as a lip balm whenever you feel your lips are dry.

At Vibrant Skin Bar, the Lip Duo kit costs $90.

9. Pro-Heal Serum Advance+

iS Clinical Pro-Heal Serum Advance

Pro-Heal Serum Advance+ is designed for all skin types and age groups, but it is especially beneficial for people with aging and compromised skin. The formulation includes a combination of soothing bioflavonoids, scientifically advanced L-ascorbic acid, vitamin E, and retinol to minimize the appearance of premature aging signs.

Key ingredients include:

  • Olive leaf extract - minimizes blemishes and nurtures the skin.
  • Retinol (vitamin A) - the most effective anti-aging ingredient; helps repair skin damage and supports healthy skin.
  • Vitamin E - repairs photodamage and provides hydration.
  • Vitamin C - protects and soothes the skin.

Apply it evenly on clean skin in the evening.

At Vibrant Skin Bar, Pro-Heal Serum Advance+ (1 oz) costs $158.

10. Reparative Moisture Emulsion

iS Clinical Reparative Moisture Emulsion

Reparative Moisture Emulsion uses pharmaceutical-grade botanicals and peptides to deeply moisturize the skin. Antioxidants in the formulation protect the skin from environmental factors and minimize aging signs.

Active ingredients include:

  • Superoxide dismutase (SOD)
  • Hyaluronic acid
  • Beet root extract - provides deep hydration and antioxidant protection.
  • Copper tripeptide growth factor - helps reduce wrinkles and other aging signs.
  • Extremozymes® - an innovative combination of enzymes that limit DNA damage from external stressors.

Massage the product into clean skin once or twice daily.

At Vibrant Skin Bar, Reparative Moisture Emulsion (1.7 oz) costs $105.

11. Sheald Recovery Balm

iS Clinical Sheald Recovery Balm

Sheald Recovery Balm is specially formulated for dry, distressed, or post-procedure skin because it dramatically replenishes moisture and soothes irritation and redness.

Oat kernel extract in the product provides antioxidant protection, while ceramides, hyaluronic acid, and glycerin deeply hydrate the skin.

Use it twice a day or whenever needed on open wounds and scars.

At Vibrant Skin Bar, Sheald Recovery Balm costs $75.

12. Super Serum Advance+

iS Clinical Super Serum Advance

Super Serum Advance+ is a high-performing, clinically proven anti-aging product. It uses a powerful combination of a 15% concentration of L-ascorbic acid and copper tripeptide growth factor to reduce wrinkles, fine lines, uneven skin, raised acne scars, and even stretch marks.

Key ingredients include:

  • L-ascorbic acid
  • Copper tripeptide growth factor
  • Centella asiatica
  • Arbutin and mushroom extract
  • Hyaluronic acid

Apply 3-5 drops and smooth evenly over clean face and neck. Use it in the morning and optionally in the evening.

At Vibrant Skin Bar, Super Serum Advance+ (1 oz) costs $158.

Note: Read our article and find out when to start using anti-aging products.

13. Youth Eye Complex

iS Clinical Youth Eye Complex

Youth Eye Complex is an effective treatment for the most common signs of aging around the eyes: wrinkles, puffiness, and dark circles.

Here’s an overview of the product’s active ingredients and what they do:

  • Copper tripeptide growth factor, acetyl octapeptide-3, and retinyl palmitate help reduce fine lines and wrinkles.
  • Pseudoalteromonas ferment extract minimizes puffiness.
  • Hyaluronic acid provides deep hydration to plump and smooth the skin.

The cream quickly regenerates the eye area, visibly reducing the appearance of aging signs.

Lightly dab the cream around the eyes in the morning and evening.

At Vibrant Skin Bar, Youth Eye Complex (0.5 oz) costs $110.

Note: Learn how microneedling helps remove dark circles under the eyes or check out our list of Best Eye Creams for Dark Circles.

14. Youth Intensive Cream

iS Clinical Youth Intensive Cream

This anti-aging powerhouse is another iS Clinical best-seller. Youth Intensive Cream combines luxurious moisturizing, antioxidant, and resurfacing ingredients to firm, plump, and rejuvenate. The cream is fast-acting and visibly transforms the skin.

The product’s active ingredients include:

  • Vitamin C
  • Superoxide dismutase (SOD)
  • Hyaluronic acid
  • Copper tripeptide growth factor
  • Sugar cane extract
  • White willow bark extract
  • Retinyl palmitate

Apply a thin layer to clean skin on the face and neck in the morning and evening.

At Vibrant Skin Bar, Youth Intensive Cream (1.7 oz) costs $235.

15. Warming Honey Cleanser

iS Clinical Warming Honey Cleanser

Warming Honey Cleanser is a rich blend of 40% raw honey and 7% soothing botanicals. It gently exfoliates the skin and deeply cleanses the pores thanks to papaya enzymes and Japanese green tea, providing rich hydration, antioxidant protection, and nourishment. The added benefit is a pleasant, warming sensation during product use.

The cleanser also regulates problematic areas, such as large pores, and protects the skin’s natural oil barrier.

Massage the cleanser gently using circular motions. Leave on for 3-5 minutes and rinse. Use it 1-3 times a week.

At Vibrant Skin Bar, Warming Honey Cleanser (4 oz) costs $48.

16. Neckperfect Complex

iS Clinical Neckperfect Complex

Though all creams and serums are applied on the neck, Neckperfect Complex is specially designed for this often neglected and fast-aging area. The cream’s potent anti-aging, hydrating ingredients improve the neck’s firmness, visibly reduce wrinkles, and improve skin tone.

Key ingredients include:

  • Hyaluronic acid
  • Bilberry extract
  • Sweet almond extract
  • Willow bark extract
  • Sugar maple extract
  • Vitamin B5
  • Green tea
  • Salicylic acid

Apply a thin layer evenly to clean skin on the neck and décolletage. Use it in the morning and evening.

Neckperfect Complex (1.7 oz) costs $105.

17. Extreme Protect SPF 30

iS Clinical Extreme Protect SPF 30

Sunscreen is the most important skincare product, according to skin experts. After cleansing and nourishing the skin, use a broad-spectrum sunscreen to prevent further damage from UV rays and environmental factors.

iS Clinical’s Extreme Protect SPF 30 minimizes DNA damage from UV radiation and contains soothing ingredients that reduce redness. Zinc oxide and octinoxate in the product offer physical and chemical protection from UVA and UVB rays, while aloe vera provides rich anti-inflammatory and moisturizing properties, helping to regenerate the skin.

Apply it generously 15 minutes before sun exposure and reapply every two hours.

Extreme Protect SPF 30 (3.5 oz) costs $80.

Note: Learn how to choose a sunscreen.

18. Youth Body Serum

iS Clinical Youth Body Serum

Aging signs are the most apparent where the skin is most exposed – on the face, neck, and hands. However, the body also loses collagen and elastin, resulting in wrinkled, dehydrated, and sagging skin, which needs nourishment and hydration.

iS Clinical uses the same advanced, scientifically based approach for body skincare products, and their Youth Body Serum delivers exceptional rejuvenating results.

It is a lightweight serum mist infused with hyaluronic acid, watermelon extracts, blue-micro algae, licorice root, vitamin B5, and extremozymes®. This potent mix of ingredients intensely hydrates, softens, and smooths the skin.

Spray on the body as desired. It is ideal for use after sun exposure.

Youth Body Serum (6.7 oz) costs $120.


Relying on superior ingredients and hard science for their formulations, iS Clinical products have gained recognition among medical cosmetic professionals and consumers because they consistently deliver stellar results.

The Vibrant Skin Bar team invites you to try our recommendations and experience the amazing rejuvenating effects of iS Clinical products.

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About the Author:
Kristina Cadwell
PA Kristina Cadwell graduated from Arizona State University with a Bachelor of Science degree in Biology. She then completed the Physician Assistant program at A.T. Still University graduating with a Masters of Medical Science degree. Kristina has been working in the Aesthetic Medical field for over 10 years. She is certified in neurotoxin cosmetic injection, dermal fillers, Plasma Pen skin tightening, chemical peels, and laser therapy. She is known for producing natural results and has extensive knowledge in diet and exercise allowing her to help you achieve vibrant skin from the inside out.
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