Juvéderm vs. Sculptra: What’s the Difference?

Dermal fillers have gained worldwide popularity as a non-invasive alternative to cosmetic surgery, offering instant, natural-looking results. In less than an hour, you can get more volumized facial contours, smoother skin, and fuller lips.

This article compares two popular filler brands, Juvéderm and Sculptra, and explores their respective benefits, potential side effects, and expected outcomes.

What Is Sculptra?

Sculptra is an FDA-approved, semi-permanent filler used to treat nasolabial folds or smile lines, chin wrinkles, and marionette lines. It is also used off-label to address skin laxity, cellulite, and volume loss in areas such as the upper arms, neck, chest, knees, hips, buttocks, and thighs.

Sculptra’s main ingredient is poly-L-lactic acid (PLLA), a synthetically sourced material that stimulates collagen production and triggers the body’s natural healing response. New collagen is built gradually, restoring the skin’s inner structure and facial volume while softening wrinkles and folds.

The effects of Sculptra fillers typically last up to two years.

Note: Read about how Radiesse and Sculptra fillers compare.  

What Is Juvéderm?

Juvéderm is a temporary, hyaluronic acid (HA)-based filler used to treat wrinkles, folds, and hollow areas in the lower face, including the lips, cheeks, jawline, and tear troughs (under-eye area).

Juvéderm injections restore lost facial volume using hyaluronic acid (HA), a naturally occurring substance that makes the skin smooth, firm, and elastic. As we age, HA production slows, leading to wrinkles, sagging, and reduced elasticity.

Over time, the body breaks down the injected hyaluronic acid. Results typically last between 6 and 18 months. However, if you are dissatisfied with the outcome, you can dissolve the filler with hyaluronidase injections.

Note: Learn about hyaluronic acid lip fillers and compare Juvéderm and Restylane for lip enhancement.

Sculptra vs. Juvéderm: What Are the Differences?

The following table summarizes Sculptra and Juvéderm key differences and similarities.

Note: Read about how Juvéderm compares to Botox, Restylane, Versa, and Radiesse.

How Do Sculptra and Juvéderm Work?

These filler injectables work differently to restore facial volume and redefine the features.

Sculptra

Sculptra reduces signs of aging in the midface and lower face by stimulating the body’s natural collagen production. As a collagen stimulator, poly-L-lactic acid (PLLA) gradually restores the skin’s internal structure, leaving it smoother, firmer, and more resilience.

PLLA particles slowly trigger collagen regeneration, which is why results are not immediate and usually develop over several weeks to months. Sculptra is often compared to planting seeds, as the process requires time and patience to reveal visible improvements.

Juvéderm
Juvéderm products contain hyaluronic acid, which instantly adds volume and enhances natural contours while smoothing wrinkles, creases, and other textural irregularities. The injections also include lidocaine, a numbing agent that minimizes discomfort during the procedure.

The concentration of hyaluronic acid varies across Juvéderm formulations, depending on the specific treatment area and desired outcome. Results typically last between 6 to 18 months as the body gradually metabolizes the filler.

Sculptra vs. Juvéderm Treatment Areas

Sculptra fillers are FDA-approved to treat:

• Marionette lines
• Nasolabial folds
• Chin wrinkles
• Cheeks
• Restoration of facial fat loss in HIV patients

Sculptra has many off-label uses, such as treating thigh and buttock cellulite and wrinkles on the elbows, knees, abdomen, chest, jawline, and temples.

Juvéderm fillers are FDA-approved for the following facial areas:

• Marionette lines
• Chin and jawline
• Nasolabial folds
• Cheeks
• Lips
• Perioral lines
• Under-eye hollowing

Juvéderm is commonly used in an off-label procedure to treat temples, forehead lines, glabellar lines, crow’s feet, neck, hands, and chest. If you decide to undergo an off-label procedure, choose a highly experienced injector to minimize the risk of filler migration, bruising, swelling, and other complications.

What Are the Benefits of Sculptra and Juvéderm?

Both filler brands offer a host of skin benefits, ranging from instant rejuvenation to longer-lasting smoothness. Depending on your aesthetic goals, you can expect different advantages.

Sculptra

Sculptra’s key benefits include the following:

• Collagen stimulation
• Skin regeneration
• Long-term rejuvenation
• Improved elasticity
• Smoother texture
• Restored facial structure
• Subtle lifting effect
• Gradual improvements
• Subtle, natural-looking results
• Two years duration with proper maintenance

Juvéderm

Juvéderm injections offer the following benefits:

• Immediate results
• Restored volume
• Wrinkle reduction
• Smoother texture
• Enhanced facial contours
• Customizable formulations
• Temporary and reversible with hyaluronidase

Do Sculptra and Juvéderm Require Special Preparation?

The following steps will help prepare you for the procedure and minimize the risk of side effects:

• Arrive with a clean, makeup-free face and use only gentle, microbiome-friendly products to wash your face before the appointment.
• Avoid blood-thinning medication and supplements, such as aspirin, ibuprofen, fish oil, vitamin E, ginkgo biloba, garlic, turmeric, and ginger to reduce bruising.
• Limit alcohol and nicotine intake 24-48 hours before the procedure.
• Discuss any medical conditions, allergies, or previous cosmetic procedures with your provider.
• Follow the specific guidelines prescribed by your provider based on the filler brand and the treatment area.

Sculptra vs. Juvéderm Procedure

Sculptra and Juvéderm treatments are quick, walk-in procedures, with the injection process typically lasting 15-20 minutes. If a patient opts for a topical numbing cream, the treatment may extend to about an hour.

The provider cleanses the treatment area and applies a topical anesthetic. The filler is then injected into targeted areas using a fine, sterile needle. The provider may gently massage the area to ensure even distribution and smooth, natural-looking results.

Sculptra requires two to three sessions spaced several weeks apart for full results, whereas a Juvéderm treatment is typically completed in one session. After each procedure, most patients can resume daily activities immediately, though mild redness, swelling, or bruising may occur at the injection site.

Sculptra vs. Juvéderm Results

The effects of Sculptra appear gradually, as it takes time to rebuild depleted collagen. After three to four treatments, the skin looks smoother, plumper, and natural-looking. Results appear after 4 to 6 weeks, peak after 3 to 6 months, and typically last up to two years.

Juvéderm fillers provide immediate results: lifted skin, volumized cheeks, and lips, and softened or eliminated wrinkles. One treatment is enough for most patients, but the number of syringes and touch-up sessions depends on your beauty goals. The effects last 6 to 18 months, depending on the treatment area, amount of filler injected, and the patient’s activity level and metabolism.

Note: Find out how long Juvéderm lasts in the lips.

What Are the Side Effects of Sculptra and Juvéderm?

You may experience mild side effects that subside after 3 to 4 days:

• Redness
• Swelling
• Bruising
• Redness
• Itching
• Tenderness
• Soreness
• Pain
• Rash
• Sensitivity at the injection site
• Small lumps or bumps

Poor injection technique or improper aftercare may result in firm bumps or nodules that persist for weeks or even months after treatment. That is why it is crucial to choose an experienced injector with a thorough understanding of facial anatomy and precise filler placement techniques.

Should Anyone Avoid Sculptra or Juvéderm?

Sculptra and Juvéderm fillers are not recommended if you:

• Pregnancy
• Breastfeeding
• History of keloid or hypertrophic scarring
• Compromised immune system
• Autoimmune or connective tissue disorders
• Bleeding disorders that affect wound healing
• Severe allergies or anaphylaxis
• Active infections, cold sores, or inflammation
• Allergy to hyaluronic acid, poly-L-lactic acid, lidocaine, or other ingredients

Juvéderm vs. Sculptra Aftercare

The following post-treatment guidelines will ensure the maximum benefit from Sculptra and Juvéderm injections:

• Refrain from strenuous exercise, such as running, jogging, or cardio activities.
• Avoid touching, rubbing, or massaging the treated areas.
• Stay well hydrated to support healing and filler integration.
• Avoid excessive heat, such as direct sun exposure, saunas, and hot tubs.
• Do not drink alcohol for 24 to 48 hours after treatment.
• Clean the skin with gentle soaps and avoid makeup for 12 to 24 hours.
• Sleep with your head elevated as instructed by your provider.
• Apply cold compresses to alleviate swelling and ease discomfort.
• Do not schedule any facial treatments, lasers, or chemical peels for two weeks.

Sculptra vs. Juvéderm Cost

The average price for a Juvéderm treatment ranges from $600 to $900, whereas one Sculptra treatment can cost you anywhere from $800 to $1,200 per vial. The overall price depends on the number of sessions, treatment area, amount of product used, and the clinic’s location and expertise.

At Vibrant Skin Bar, we offer:

• Sculptra® (per vial) and Sculptra® Butt Lift | $900 (per vial)
• Juvéderm Volbella | $625 (per syringe)
• Juvéderm Ultra and Ultra Plus | $649 (per syringe)
• Juvéderm Vollure | $749 (per syringe)
• Juvéderm Volux | $749 (per syringe)
• Juvéderm Voluma | $850 (per syringe)

Note: Read about Sculptra and other non-surgical butt lift solutions.

Sculptra vs. Juvéderm FAQ

You may still be wondering which filler brand is more suitable for you and whether you can safely combine them. Read the answers to the most frequently asked questions to resolve all dilemmas.

Can I Get Sculptra and Juvéderm Together?

Sculptra and Juvéderm can be done during the same session. Juvéderm’s instant fullness, hydration, and smoothness complement Sculptra’s long-term collagen regrowth, restored volume, and structural lift.

The injector will use a layered approach and different placement strategies to inject both fillers for enhanced volume, definition, and firmness.

Can I Reverse Sculptra and Juvéderm?

Juvéderm can be fully reversed with hyaluronidase injections. The process typically requires only one session, though multiple treatments may be necessary for complete reversal.

There are no reversal agents for Sculptra, as it is made of poly-L-lactic acid, a biostimulator made of a synthetic polymer that fully integrates into the body’s natural tissue.

If you are dissatisfied with the outcome of Sculptra, you can undergo a surgical procedure or consult your medical provider about less invasive removal methods, such as steroid injections.

Should I Choose Sculptra or Juvéderm?

Sculptra and Juvéderm fillers are injected in a similar way and provide comparable results, but their active ingredients, longevity, and treatment areas differ. During the consultation, your medical provider will inquire about your skin concerns and aesthetic goals to help you decide.

Choose Sculptra to address hollow cheeks, deep nasolabial folds, marionette lines, and chin, and if you would like:

• Natural, long-term results
• Deep rejuvenation
• Collagen stimulation
• Subtle, gradual improvements

Opt for Juvéderm to treat the lips, cheeks, marionette lines, nasolabial folds, chin, jawline, and tear troughs, and also get:

• Immediate wrinkle reduction
• Instant volume boost
• Enhanced contours
• Hydrated and plump skin

Conclusion

Sculptra and Juvéderm effectively reverse the signs of aging, justifying the popularity that they have gained. Choose an experienced and certified dermal filler provider, who will determine the best product for your skin goals and will deliver results you will proudly wear for a long time.

Contact our Vibrant Skin Bar experts to see which brand is best suited for your skin concern.