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Zinc and Botox: Does Zinc Enhance the Effects of Botox?

Kristina Cadwell  
August 29, 2024  

Each year, millions of people use Botox to reverse the effects of skin aging. Few treatments can match its effectiveness in smoothing wrinkles. However, Botox has a few limitations, one of which is the treatment’s relatively short duration. 

Botox results typically last three to six months, but some patients’ wrinkles reappear sooner. Providers advise patients to adhere to specific instructions before and after the treatment to increase its effectiveness and longevity. In many cases, it involves taking zinc supplements.

This article discusses the relationship between zinc and Botox, explaining whether the combination can enhance Botox results.

How Zinc affects the Botox treatment

‌Does Zinc Help Botox Last Longer?

Many Botox providers recommend taking zinc supplements prior to the Botox treatment because anecdotal evidence suggests it boosts results in several ways. Here are the ways in which zinc is thought to help Botox patients:

  • It can help reduce inflammation post-injection.
  • It promotes collagen synthesis, further smoothing the skin.
  • It may prolong Botox results.

Research shows Botox is a zinc-dependent protein, requiring adequate levels of zinc to effectively block the neurotransmitter release and paralyze target muscles causing wrinkles. However, scientists don’t know if zinc insufficiency impacts the effectiveness of Botox.

A study in 2012 showed that candidates who took zinc supplements with phytase (a digestive enzyme that increases zinc absorption) experienced a nearly 30% increase in the treatment’s effectiveness and duration.

Another study on the effects of zinc on Botox for gummy smile suggests zinc supplementation before the treatment provided a “long-term decreased amount of gingival display”.

Though research shows promise, scientists maintain that the evidence for zinc’s potential to enhance Botox results is inconclusive and that more studies are needed.

When Should You Combine Zinc and Botox?

There is no defined protocol for taking zinc for Botox. Doctors typically prescribe zinc supplements with digestive enzymes to be taken four days before the treatment and on the day of the treatment. Some doctors recommend two capsules daily, one in the morning and one in the evening.

People who have proven zinc deficiency may benefit from zinc IV infusion before the treatment to ensure higher mineral absorption.

How Much Zinc Makes Botox Last Longer?

Study participants whose Botox results lasted 30% longer received a dose of 50 mg of zinc citrate with 3,000 PU phytase daily (for five days).

Patients who received 10 mg of zinc gluconate didn’t see a significant change from the average Botox duration.

There is no prescribed zinc dosage for the purpose of enhancing Botox results. Some doctors prefer to err on the side of caution, prescribing 15 mg supplements or encouraging patients to increase their zinc levels through diet (oysters, meat, beans, nuts, whole grains, etc.).


Note: Learn more about what to consider before getting Botox.


How Much Zinc Is Too Much?

The National Institutes of Health sets an upper zinc intake limit of 40 mg a day. Dosages that exceed that limit, such as the 50 mg daily before Botox treatments, are considered safe if used for a short period.

Long-term, high-dose zinc supplementation can cause abdominal pain, diarrhea, vomiting, and copper deficiency. Always consult your healthcare provider before taking any new supplements.

Conclusion

Botox provides amazing results, but they are short-lived. To maintain smooth, wrinkle-free skin for longer, learn how to prepare for Botox treatment and what are the best Botox aftercare tips, and try zinc supplements per your provider’s instructions.

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About the Author:
Kristina Cadwell
PA Kristina Cadwell graduated from Arizona State University with a Bachelor of Science degree in Biology. She then completed the Physician Assistant program at A.T. Still University graduating with a Masters of Medical Science degree. Kristina has been working in the Aesthetic Medical field for over 10 years. She is certified in neurotoxin cosmetic injection, dermal fillers, Plasma Pen skin tightening, chemical peels, and laser therapy. She is known for producing natural results and has extensive knowledge in diet and exercise allowing her to help you achieve vibrant skin from the inside out.
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