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Microbiome Skin Care: Things You Need to Know

Kristina Cadwell  
May 7, 2025  

Around a thousand species of bacteria and other microorganisms inhabit human skin, forming the skin microbiome. Microbiome skin care prioritizes maintaining a balanced skin ecosystem by supporting beneficial bacteria and strengthening the skin barrier.

This article explains how microbiome skin care works and gives practical ways to maximize its skin-enhancing potential.

Microbiome Skin Care: Things You Need to Know

What Is Microbiome in Skin Care?

The skin microbiome, or skin flora, consists of trillions of microorganisms - including bacteria, fungi, viruses, and yeast - which form a protective barrier against pathogens, infections, and environmental pollutants. These microbes also interact with the immune system, helping to maintain a healthy and intact skin barrier.

Microbiome-balancing skincare products strengthen the skin’s natural defenses and support a thriving skin ecosystem. They may include beneficial bacteria or nourishing ingredients that help maintain microbial balance and enhance the skin’s resilience.

How Does Microbiome Skin Care Work?

Microbiome skincare contains prebiotics, probiotics, and postbiotics that foster a balanced microbial environment, bolster the skin’s natural defenses, and enhance the barrier.

It improves skin quality in the following ways:

  • Regulates microbial balance – Creates an optimal environment for beneficial bacteria while inhibiting the growth of harmful bacteria.
  • Maintains a healthy skin ecosystem - Maintains a healthy balance of good and bad bacteria to preserve a rich and diverse skin flora.
  • Preserves the skin barrier – Strengthens the protective barrier to fend off pathogenic threats and prevent environmental damage.
  • Enhances skin resilience – Boosts the skin’s natural defense system and makes it more resilient against internal and external stressors.
  • Boosts hydration – Helps the skin retain moisture, prevent water loss, and maintain optimal pH levels, softening its texture and making the skin glow.
  • Promotes skin repair – Accelerates wound healing by stimulating cellular regeneration.
  • Reduces inflammation – Prevents flare-ups, redness, and inflammatory conditions like acne, eczema, and psoriasis.
  • Protects against infections – Enhances the skin’s innate immune system to help protect against harmful, disease-spreading microbes.
  • Minimizes UV damage –  Helps the skin recover from UV-induced stress, minimizing photoaging.
  • Reduces premature aging – Slows the aging process by neutralizing free radical damage and collagen breakdown.

What Are the Benefits of Microbiome Skincare?

Microbiome-balancing skincare is the first line of defense against pollution, premature aging, and inflammation. It strengthens resilience and enhances protection against environmental aggressors by supporting the skin’s natural immune system.

These are the key benefits of microbiome-friendly skincare.

Maintains the Barrier Function

Microbiome-supporting skincare strengthens the natural lipid barrier that helps seal in moisture, retain nutrients, and protect against irritants, pollutants, allergens, and UV damage.

A compromised skin barrier can lead to skin inflammation, excessive dryness, increased sun sensitivity, and overall discomfort. The primary goal of microbiome-friendly topical products is to keep the skin barrier strong and intact.

Regulates the Skin’s Microbiome

Topical treatments that focus on preserving skin microbiota promote the growth of beneficial bacteria while suppressing harmful ones. Their goal is to maintain a balanced environment where good bacteria can thrive.

An unbalanced microbiome compromises the skin barrier, leading to flare-ups and long-term skin conditions that may require medication.

Reduces the Risk of Infections

Skin flora contains microorganisms with antibiotic properties that help shield against germs and infections. Skin microbes also alert the immune system to potentially pathogenic bacteria or viruses, preventing their proliferation.

Reduces Redness and Inflammation

Microbiome skincare can mitigate skin inflammation, prevent breakouts, and accelerate healing. Its soothing, anti-inflammatory ingredients are ideal for sensitive or reactive skin types. Each product is uniquely formulated to calm symptoms like redness, itchiness, swelling, and dryness.

Maintains Optimal Hydration

Microbiome-supporting products help the skin retain moisture and natural elasticity, resulting in a natural, dewy complexion. A well-balanced microbiome minimizes transepidermal water loss by reinforcing the protective layer, strengthening the immune response, and stimulating the production of ceramides, fatty acids, and other moisturizing factors.

Rejuvenates the Skin

Microbiome skincare offers powerful anti-aging benefits by preserving elasticity, reducing signs of aging, and minimizing wrinkle formation. Its rejuvenating ingredients support skin cell renewal and combat oxidative stress, resulting in a smoother, firmer complexion. 


Note: Learn what causes loss of elasticity and how to prevent it.


Promotes Skin Repair

Studies suggest beneficial bacteria support skin repair and accelerate wound healing by activating immune cells to fight harmful microbes and prevent infections. They also aid in shedding dead skin cells by releasing enzymes that break down proteins, promoting faster recovery from irritation, minor wounds, and acne scars. Microbiome-friendly skincare may also support UV-induced DNA repair and reduce long-term harm by influencing how cells react to ultraviolet radiation.

Free from Artificial Preservatives

Artificial preservatives extend shelf life but may compromise skin health and cause long-term damage. Microbiome skincare offers natural, self-preserving alternatives to synthetic, skin-damaging ingredients like parabens, phthalates, silicones, and SLS. These chemicals may disrupt the barrier and expose the skin to harmful bacteria, triggering redness, inflammation, and breakouts.

What Are the Key Ingredients in Microbiome Skin Care?

Vibrant skincare line is enriched with microbiome-supporting ingredients that nurture a balanced skin microbiome and enhance resilience.

Probiotics, Prebiotics, and Postbiotics

Biome-supporting skin care contains probiotic, prebiotic, and postbiotic ingredients to restore healthy microflora, balan-ce skin bacteria, and promote overall skin health. Formulations may include one, two, or all three of these components.

  • Probiotic skin care – Topical and oral probiotics are living beneficial bacteria that help maintain a healthy microbial balance by supporting good bacteria and inhibiting the overgrowth of potentially harmful ones.
  • Prebiotic skin care – Prebiotic ingredients like inulin, rhamnose, beta-glucan, oligosaccharides, and glucomannan nourish good bacteria to support a healthy, thriving ecosystem.
  • Postbiotic skin care – Postbiotics, derived from probiotic fermentation, strengthen the barrier, reduce inflammation, and rejuvenate the skin. They offer enhanced bioavailability and effectiveness without the addition of prebiotics.

Vibrant Cleanse contains prebiotics, probiotics, and postbiotics, which minimize inflammation, stimulate antimicrobial resistance, restore skin immunity, and gently remove dead skin.

Vibrant Cleanse – Biome Enzyme Cleanser for all skin types

Anti-Inflammatory Ingredients

Microbiome skin care has the following ingredients that have proven anti-inflammatory properties:

  • Centella asiatica – A soothing, antioxidant humectant that reduces inflammatory acne eczema, psoriasis, and stretch marks.
  • Green tea extract – Calms inflammation, soothes irritation, and eliminates acne-causing microorganisms.
  • Niacinamide (vitamin B3) – Regulates sebum production, brightens the complexion, and calms redness and blemishes.
  • Zinc PCA – Its potent antibacterial properties promote skin healing, fight acne, and reduce redness and swelling.

BioFense INCI: Lactobacillus Ferment

BioFense is a fermented Lactobacillus-based skincare ingredient that supports skin flora by stimulating the skin’s natural defense system and the production of antimicrobial peptides that target and eliminate harmful bacteria. It was clinically tested on acne-prone skin and has outperformed salicylic acid in reducing redness and lesion size.

Black BeeOme™

Black BeeOme is a honey-based ingredient fermented with Zymomonas mobilis bacteria. Clinical studies show that it accelerates skin flora regeneration, restores the skin barrier, reduces sebum production, and evens out the complexion. It supports microbiome recovery, particularly when disrupted by environmental stressors like pollution.

Nectaria Lithops™

Nectaria lithops is a natural active ingredient that stimulates vitamin D production, creating an optimal skin microenvironment for deep hydration. It improves skin tone, texture, and microcirculation, helping to revitalize the skin and brighten the complexion. Vitamin D offers many benefits, including stronger barrier, moisture loss prevention, lower inflammation, and improved cell turnover.

Vibrant Elevate toner has a unique blend of natural ingredients like cucumber, matcha green tea, Tonka bean prebiotic, and Nectaria lithops™ that support the skin’s natural microbiome.

Vibrant Elevate – Cucumber Photodynamic Toner

Wild Indigo Extract

Wild indigo, or neurophroline, is a potent anti-inflammatory antioxidant agent that prevents premature aging and brightens the complexion. It reduces cortisol production by 70% and counteracts visible signs of stress on the skin by triggering the release of a calming, pain-relief neuropeptide (beta-endorphin) by 163%. It can improve under-eye complexion and even skin tone, restoring its natural luminosity.

Desert Vibe is a moisture-boosting serum packed with barrier-supporting ingredients like beta-glucan, centella, neurophroline, and prickly pear. This powerful antioxidant formula regenerates collagen, boosts skin immunity and binds more moisture than hyaluronic acid.

Desert Vibe Serum – Moisture Boosting Serum

The Best Microbiome Skin Care Treatments for Different Skin Types

When selecting a microbiome-friendly skincare product, consider your skin type and specific concerns, such as acne, dryness, or eczema. Each formula is designed to address your needs while preserving the skin’s delicate microbiome balance.

Microbiome Skin Care for Dry Skin

Dry skin can benefit from barrier-repairing creams that seal in moisture and prevent water loss. Choose lightweight, microbiome-repairing serums, masks, and hydrating mists with probiotics and prebiotics. Avoid alcohol-based products to prevent dehydration.

Microbiome Skin Care for Oily, Acne-Prone Skin

Choose gentle, pH-balanced formulations that target acne and help reduce oiliness and sebum production. Use cleansers and moisturizers for oily skin with fermented skincare ingredients that can prevent breakouts and calm the skin.


Note: Read about the best skincare products for oily, acne-prone skin.


Microbiome Skin Care for Sensitive Skin

If you have sensitive skin or conditions like rosacea, eczema, or psoriasis, choose microbiome-friendly treatments that restore microflora, strengthen the barrier, and minimize the stress on the skin. Choose probiotic-infused serums and creams with anti-inflammatory properties and reparative, barrier-strengthening ingredients like ceramides. Stick to soothing, fragrance-free formulations to help reduce flare-ups and calm irritation.

Microbiome Skin Care for Mature Skin

Microbiome skincare offers powerful anti-aging benefits by slowing collagen and elastin breakdown, stimulating skin renewal, and reducing wrinkles and sagging. Look for barrier-reinforcing creams and postbiotic-rich serums that boost hydration, support collagen production, and enhance elasticity and firmness.


Note: Learn what is the best time to start using anti-aging skincare.


Microbiome Skin Care for Normal and Combination Skin

Normal and combination skin do not require targeted treatments for specific concerns but can benefit from microbiome-supporting skin care to maintain microbial diversity and overall skin health. Use lightweight, non-comedogenic products for combination skin and barrier-strengthening, hydrating ingredients for normal skin.

What Is the Best Microbiome Skin Care Routine?

Tailor your skincare routine to your skin’s needs while keeping it simple to protect the microbiome from heavy, stripping ingredients.

The ultimate skincare guide can help you master the basics and learn about each step.

Morning Routine

Follow these biome-supporting skincare steps for your morning routine:

  1. Cleanser – Choose a mild product to thoroughly cleanse the skin without over-drying it.
  2. Toner – Use a toner with prebiotics or probiotics to balance the skin and remove excess dirt.
  3. Serum or oil – Apply a lightweight, pH-balanced serum or superfood oil to nourish the skin and reduce senescent (zombie) cells.
  4. Moisturizer – Seal in moisture with a hydrating, microbiome-balancing moisturizer.
  5. Sunscreen – Apply a broad-spectrum, high-SPF, mineral-based sunscreen and avoid chemical formulas that can disturb the microbiome and cause irritation.

Note: Vibrant Neuro Vibe is a superfood oil that you can apply to all skin types twice a day after toner. The formula contains twenty-one nutrient-dense oils and a prebiotic plant called Kannabia Sense™ that restores vitality, stimulates oxytocin, and minimizes zombie cells.


Vibrant Neuro Vibe

Evening Routine

Finish your day with the following microbiome-friendly routine:

  1. Makeup remover – Remove makeup and sunscreen with gentle, plant-based ingredients that will not strip natural oils and disrupt the microbiome.
  2. Cleanser – Use an oil-based, low-foam cleanser to gently remove all impurities, dirt, and oil accumulated throughout the day.
  3. Toner – Choose a mild, minimally formulated toner with natural, soothing extracts.
  4. Serum – Apply a hydrating, probiotic-infused serum to lock in extra moisture.
  5. Moisturizer – Use a nourishing, barrier-repairing overnight cream with ceramides or postbiotics to fortify the barrier overnight.
  6. Face mask – Apply a microbiome-boosting mask once or twice a week to nourish, soothe, and fortify the protective barrier.

Note:  Vibrant Mud is a probiotic-enriched mask with bentonite clay, kaolin clay, and activated charcoal. It deeply cleanses the skin, unclogs the pores, and brightens the complexion while restoring its natural microbiome.


Vibrant Mud – Clarifying Clay Mask

How Long Does It Take to See the Results of Microbiome Skin Care?

Since everyone’s skin responds differently, results will differ for each person. However, you may see improvements within days to weeks after starting a postbiotic skincare routine and incorporating probiotic-rich, whole foods into your diet.

  • You may notice improved hydration, calmer skin, and reduced redness in the first two weeks.
  • Achieving noticeable results may take several months for chronic skin concerns like rosacea, eczema, and acne.

Consistent use of microbiome-friendly skin care is key to maintaining results and achieving long-term skin health.

Can Microbiome Skin Care Be Combined with Other Ingredients?

You can complement your skincare regimen with barrier-strengthening ingredients that promote collagen production and deeply hydrate all skin layers.

These ingredients can enrich your biome-supporting routine:

  • Ceramides – Preserve the skin barrier, prevent water loss, and protect against UV damage.
  • Niacinamide – Regulates sebum production, reduces acne, and fortifies the barrier.
  • Hyaluronic acid – Moisturizes the skin, enhances elasticity, and minimizes wrinkles.
  • Aloe vera– Calms sensitive skin, reduces breakouts and deeply hydrates the skin.
  • Vitamin A– Improves skin elasticity, minimizes UV damage, and reduces acne.
  • Vitamin C – Brightens skin tone and provides antioxidant protection.
  • Vitamin D – Aids in repairing damaged skin and supports the barrier function.
  • Peptides – Promote skin repair and collagen production.
  • Zinc – Reduces inflammation, redness, and irritation.

What to Avoid in Microbiome Skin Care?

The following precautionary measures can help you maintain a healthy microbial balance:

  • Avoid excessive washing as it can strip away beneficial bacteria from the surface.
  • Do not layer too many products to prevent overwhelming and irritating your skin.
  • Avoid harsh exfoliators and use only gentle alternatives like beta-glucan, lactic acid, or PHA.
  • Do not overuse products with potent active ingredients to avoid increased sensitivity, breakouts, or irritation.
  • Stop using a product if you notice discomfort like itching, burning sensations, or redness.

Conclusion

A balanced skin microbiome is the cornerstone of healthy, radiant skin. Microbiome-friendly skincare not only defends against harmful substances but also revitalizes and enhances your skin’s natural glow. By promoting microbial diversity and reinforcing the skin’s protective barrier, these products help prevent damage from environmental pollutants, stress, and daily skincare routines - keeping your complexion strong, resilient, and vibrant.

Learn more about skin flora and microbiome skincare from our Vibrant experts.

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About the Author:
Kristina Cadwell
PA Kristina Cadwell graduated from Arizona State University with a Bachelor of Science degree in Biology. She then completed the Physician Assistant program at A.T. Still University graduating with a Masters of Medical Science degree. Kristina has been working in the Aesthetic Medical field for over 10 years. She is certified in neurotoxin cosmetic injection, dermal fillers, Plasma Pen skin tightening, chemical peels, and laser therapy. She is known for producing natural results and has extensive knowledge in diet and exercise allowing her to help you achieve vibrant skin from the inside out.
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